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  • 產(chǎn)品名稱(chēng)： Recombinant Human Adenosine Deaminase/ADA Protein
  • 產(chǎn)品貨號(hào)： CSP11004
  • 貨期： 現(xiàn)貨
  • 價(jià)格與訂購(gòu)： 1800
  • 數(shù)量：
    庫(kù)存： 100
  • 規(guī)格： 50μg 100μg 1mg
  • 產(chǎn)品信息
  • 如何訂購(gòu)
    概述（Summary）
    英文全稱(chēng)
    Recombinant Human Adenosine Deaminase/ADA Protein
    純度（Purity）
    >95%
    蛋白構(gòu)建（Construction）
    Lys11-Val280
    Accession #
    P00813
    表達(dá)宿主（Host）
    E.coli
    種屬（Species）
    Homo sapiens (Human)
    預(yù)測(cè)N端（Predicted N-terminus）
    Inconclusive result, Met predicted. Protein identity confirmed by MS analysis of tryptic fragments
    預(yù)測(cè)分子量（Predicted Molecular Mass）
    42 kDa
    背景（Background）
    背景介紹
    Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy?adenosine to inosine and deoxyinosine (1, 2). ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages (3, 4). ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis (5). Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co?activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion (6)
    分子別名（Alternative Names）
    ADA; ADA1; adenine deaminase; Adenosine aminohydrolase; Adenosine Deaminase; EC 3.5.4.4