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  • 產(chǎn)品名稱： Recombinant Human CISH protein
  • 產(chǎn)品貨號： CSP00346
  • 貨期： 現(xiàn)貨
  • 價格與訂購： 1800
  • 數(shù)量：
    庫存： 100
  • 規(guī)格： 50μg 100μg 1mg
  • 產(chǎn)品信息
  • 如何訂購
    概述（Summary）
    英文全稱
    Recombinant Human CISH protein
    純度（Purity）
    >90% as determined by SDS-PAGE
    內(nèi)毒素（Endotoxin level）
    Please contact with the lab for this information.
    蛋白構(gòu)建（Construction）
    A DNA sequence encoding the human CISH (Met1-Leu258) was fused with His tag
    Accession #
    Q9NSE2
    表達(dá)宿主（Host）
    E.coli
    種屬（Species）
    Homo sapiens (Human)
    預(yù)測分子量（Predicted Molecular Mass）
    30.29 kDa
    制劑（Formulation）
    Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
    運輸方式（Shipping）
    In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
    穩(wěn)定性&儲存（Stability &Storage）
    Use a manual defrost freezer and avoid repeated freeze thaw cycles.
    Store at 2 to 8 °C for one week .
    Store at -20 to -80 °C for twelve months from the date of receipt.
    復(fù)溶（Reconstitution）
    Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
    背景（Background）
    背景介紹
    Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains oneSH2 domain and oneSOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
    分子別名（Alternative Names）
    Cytokine-inducible SH2-containing protein,CIS,CIS-1,Protein G18,Suppressor of cytokine signaling,SOCS.
    Note
    For research use only .