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產(chǎn)品名稱(chēng)： Recombinant Human pro-GRP Protein(C-10His)
產(chǎn)品貨號(hào)： CS06035
貨期： 現(xiàn)貨
價(jià)格與訂購(gòu)： 2200
數(shù)量：

庫(kù)存： 5
規(guī)格： 10ug

產(chǎn)品信息
如何訂購(gòu)

種屬

Human

來(lái)源

HEK 293

分子量

Detects a band of approximately 13 kD(Predicted molecular weight: 9.4 kD)

外觀(guān)

Lyophilized Powder

形態(tài)

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

序列

Ser54-Asp121

STGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDGGGGSHHHHHHHHHH

標(biāo)簽

C-10His

純度

＞95% by SDS-PAGE

內(nèi)毒素水平

< 1EU/ug

標(biāo)記

unconjugated

溶解方法

Centrifuge tubes before opening.Reconstitute no more than 0.1 mg/mL according to the size in deionized water.

儲(chǔ)存/保存方法

Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -120 °C as supplied. Avoid repeated freeze-thaw cycles.

背景說(shuō)明

Pro-Gastrin-Releasing-Peptide, also known as Pro-GRP, is a Gastrin-Releasing-Peptide (GRP) precursor, a neurotransmitter that belongs to the bombesine/neuromedin B family. GRP stimulates the secretion of gastrin in order to increase the acidity of the gastric acid. Pro-GRP is a peptide composed of 125 amino acids, expressed in the nervous system and digestive tract. In pathological situations, GRP has mitogenic activity in vitro in many tumors such as pancreatic, small cell lung (SCLC), prostate, kidney, breast and colorectal cancers. GRP could operate as an autocrine growth factor. In cancers, GRP induces cell growth and inhibits apoptosis by shutting down the endoplasmic reticulum stress pathway. As early as 1994, research on Pro-GRP as a biomarker for small cell lung cancer began. Because of the very short half-life of GRP (2 minutes), the Pro-GRP is used for measurements and analysis. Since then, Pro-GRP has been used as a tumor marker for patients with small cell lung cancer (SCLC) in limited and extended stages.

Accession

P07492

實(shí)驗(yàn)結(jié)果圖